Natural Killer T Cells: An Ecological Evolutionary Developmental Biology Perspective.
Author USMA Department
Chemistry and Life Science
USMA Center/Institute Affiliation
Center for Molecular Science
NKT cells, Cancer immunotherapy, Microbiota, Infectious diseases, Evolution
Type I natural killer T (NKT) cells are innate-like T lymphocytes that recognize glycolipid antigens presented by the MHC class I-like protein CD1d. Agonistic activation of NKT cells leads to rapid pro-inflammatory and immune modulatory cytokine and chemokine responses. This property of NKT cells, in conjunction with their interactions with antigen-presenting cells, controls downstream innate and adaptive immune responses against cancers and infectious diseases, as well as in several inflammatory disorders. NKT cell properties are acquired during development in the thymus and by interactions with the host microbial consortium in the gut, the nature of which can be influenced by NKT cells. This latter property, together with the role of the host microbiota in cancer therapy, necessitates a new perspective. Hence, this review provides an initial approach to understanding NKT cells from an ecological evolutionary developmental biology (eco-evo-devo) perspective.
Kumar, A., Suryadevara, N., Hill, T. M., Bezbradica, J. S., Van Kaer, L., & Joyce, S. (2017). Natural Killer T Cells: An Ecological Evolutionary Developmental Biology Perspective. Frontiers in Immunology, 8. doi:10.3389/fimmu.2017.01858
This work was supported by VA Merit Award (BX001444) to SJ and by research (AI042284, AI061721, AI070305, HL089667, AI068149, AI074754, and AI064639) grants.