Title

Obesity Tissue: Composition, Energy Expenditure, and Energy Content in Adult Humans

Contributing USMA Research Unit(s)

Mathematical Sciences

Publication Date

7-19-2019

Publication Title

Obesity

Document Type

Article

Abstract

OBJECTIVE: Chronic positive energy balance leads to obesity, and the "excess" weight is usually described as consisting solely of adipose tissue (AT) or its two components, fat and fat-free mass (nonfat cell mass, extracellular fluid). This study aimed to clarify the nature of "obesity" tissue.

METHODS: A total of 333 adults had AT, skin, skeletal muscle, bone, heart, liver, kidney, spleen, brain, and residual mass measured or derived using magnetic resonance imaging and dual-energy x-ray absorptiometry. First, associations between these components and AT were examined by developing multiple regression models. Next, obesity-tissue composition was developed by deriving mean component mass differences between participant groups with normal weight (BMI < 25 kg/m

RESULTS: AT significantly predicted organ-tissue mass in 17 of 18 multiple regression models. In addition to AT and skeletal muscle, the following associations were found: skin, liver, and bone were main contributors to obesity-tissue composition; liver, kidneys, and heart to resting energy expenditure; and skin, liver, and bone to metabolizable energy and protein contents. A pronounced sexual dimorphism was present in all three models.

CONCLUSIONS: Obesity is characterized not only by excess AT but by increases in the masses of other "companion" organs and tissues and their related metabolic properties.

Record links to items hosted by external providers may require fee for full-text.

Share

COinS